Beaufort High picked up a Region 7-4A win with a 13-1 victory at Hilton Head High on Monday.
Madison Sanchez went 2-for-3 with two RBIs and three runs, Carleigh Coolong was 2-for-3 with an RBI, and Lillian Bearden added a two-run double for the Eagles.
Maliyah Hagan allowed one unearned run with three strikeouts and four walks in a five-inning complete game.
Leah Anderson was 2-for-3 and Reagan Marchant added a hit for the Seahawks.
Beaufort (3-8, 2-2) hosts the Seahawks (6-7, 0-4) for the second game of the series at 7 p.m. Wednesday.