May River opened region play with a 17-1 road win over Lake Marion on Tuesday.
Giovana Rodriguez threw a three-inning no-hitter, allowing one run and two walks with three strikeouts.
Hannah Manley was 2-for-2 with a triple, two runs, and three RBIs, Kylee Gleason was 2-for-2 with three runs and two RBIs, and Peyton Rockwell was 2-for-3 with an RBI and a run.
The Sharks (2-1) host the Gators for a rematch Friday.