May River opened region play with a 13-1 home win over Lake Marion on Tuesday.
Kamryn Gleason and Blaine Clavel combined on a five-inning no-hitter for the Sharks. Gleason struck out seven and walked one over three scoreless innings to earn the win, and Clavel gave up one walk and one unearned run in two frames.
Josh Patterson was 3-for-3 with a triple, a homer, three runs, and six RBIs to lead the Sharks at the plate. Josh Reddy was 2-for-3 with a triple, and Gleason drove in two runs.
The Sharks (3-3) travel to Colleton County on Thursday.
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